We consider optimal itinerary problems in time-table information systems supporting a vast number of on-line queries. We exhibit two important extensions of the time-dependent approach to model realistic versions of the Earliest Arrival and Minimum Number of Transfer problems, as well as of a combination of them, that could not be modeled by the original version of the time-dependent approach. We also provide heuristics that speed up implementations and present preliminary experimental results with real-world data.